Heterocyclic Boron Acid Catalyzed Dehydrative Amidation of Aliphatic/Aromatic Carboxylic Acids with Amines

A commercially available and versatile dehydrative amidation catalyst, featuring a thianthrene boron acid structure, has been developed. The catalyst shows high catalytic activity to both aliphatic and less reactive aromatic carboxylic acid substrates, including several bioactive or clinical molecul...

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Bibliographic Details
Published inJournal of organic chemistry Vol. 88; no. 5; pp. 2832 - 2840
Main Authors Pan, Bin, Huang, Ding-Min, Sun, Hao-Tian, Song, Sheng-Nan, Su, Xian-Bin
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 03.03.2023
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
PALLADIUM
DIRECT AMIDE FORMATION
ACTIVATION
CARBON
MECHANISTIC INSIGHTS
PEPTIDE-BOND FORMATION
CONDENSATION
ALDEHYDES
TRANSAMIDATION
EFFICIENT
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Summary:A commercially available and versatile dehydrative amidation catalyst, featuring a thianthrene boron acid structure, has been developed. The catalyst shows high catalytic activity to both aliphatic and less reactive aromatic carboxylic acid substrates, including several bioactive or clinical molecules with a carboxylic acid group.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.2c02515