Metal-Free Radical Oxidative Annulation of Ynones with Alkanes To Access Indenones

The benzoyl peroxide (BPO) promoted carboannulation of ynones with alkanes is developed, affording a series of 2-alkyl-3-aryl indenones in moderate to good yields. The procedure involves direct functionalization of alkane C­(sp3)–H and arene C­(sp2)–H bonds under metal-free conditions, providing a f...

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Published inJournal of organic chemistry Vol. 81; no. 5; pp. 2087 - 2093
Main Authors Pan, Changduo, Huang, Bifan, Hu, Weiming, Feng, Xiaomei, Yu, Jin-Tao
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 04.03.2016
Amer Chemical Soc
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Summary:The benzoyl peroxide (BPO) promoted carboannulation of ynones with alkanes is developed, affording a series of 2-alkyl-3-aryl indenones in moderate to good yields. The procedure involves direct functionalization of alkane C­(sp3)–H and arene C­(sp2)–H bonds under metal-free conditions, providing a favorable approach for indenone synthesis.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.6b00072