Metal-Free Radical Oxidative Annulation of Ynones with Alkanes To Access Indenones
The benzoyl peroxide (BPO) promoted carboannulation of ynones with alkanes is developed, affording a series of 2-alkyl-3-aryl indenones in moderate to good yields. The procedure involves direct functionalization of alkane C(sp3)–H and arene C(sp2)–H bonds under metal-free conditions, providing a f...
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Published in | Journal of organic chemistry Vol. 81; no. 5; pp. 2087 - 2093 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
WASHINGTON
American Chemical Society
04.03.2016
Amer Chemical Soc |
Subjects | |
Online Access | Get full text |
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Summary: | The benzoyl peroxide (BPO) promoted carboannulation of ynones with alkanes is developed, affording a series of 2-alkyl-3-aryl indenones in moderate to good yields. The procedure involves direct functionalization of alkane C(sp3)–H and arene C(sp2)–H bonds under metal-free conditions, providing a favorable approach for indenone synthesis. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0022-3263 1520-6904 |
DOI: | 10.1021/acs.joc.6b00072 |