NIR-II Responsive Nanohybrids Incorporating Thermosensitive Hydrogel as Sprayable Dressing for Multidrug-Resistant-Bacteria Infected Wound Management

• Published in: ACS nano Vol. 17; no. 12; pp. 11253 - 11267
• Main Authors: Pan, Weilun, Wu, Bodeng, Nie, Chengtao, Luo, Tingting, Song, Zhenli, Lv, Jie, Tan, Yong, Liu, Chunchen, Zhong, Mingzhen, Liao, Tong, Wang, Zhenxun, Yi, Guanghui, Zhang, Limin, Liu, Xiaoliu, Li, Bo, Chen, Jinxiang, Zheng, Lei
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 27.06.2023
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Bacteria; Bandages; Humans; Hydrogels - chemistry; Hydrogels - pharmacology; Inflammation; Reinfection; Wound Infection - drug therapy; multidrug resistance; wound healing; antibacterial; NIR-II responsive materials; thermosensitive hydrogel
• ISSN: 1936-0851; 1936-086X
• DOI: 10.1021/acsnano.2c10742

Developing an effective dressing against bacterial infection and synchronously addressing wound complications, such as bleeding, long-term inflammation, and reinfection, are highly desirable in clinical practice. In this work, a second near-infrared (NIR-II) responsive nanohybrid consisting of imipenem encapsulated liposome with gold-shell and lipopolysaccharide (LPS)-targeting aptamer, namely ILGA, is constructed for bacteria elimination. Benefiting from the delicate structure, ILGA exhibits strong affinity and a reliable photothermal/antibiotic therapeutic effect toward multidrug-resistant Pseudomonas aeruginosa (MDR-PA). Furthermore, by incorporating ILGA with a thermosensitive hydrogel poly­(lactic-co-glycolic acid)–polyethylene glycol–poly­(lactic-co-glycolic acid) (PLGA-PEG-PLGA), a sprayable dressing ILGA@Gel was prepared, which enables a quick on-demand gelation (10 s) for wound hemostasis and offers excellent photothermal/antibiotic efficacy to sterilize the infected wound. Additionally, ILGA@Gel provides satisfactory wound-healing environments by reeducating wound-associated macrophages for inflammation alleviation and forming a gel layer to block exogenous bacterial reinfection. This biomimetic hydrogel reveals excellent bacteria eradication and wound recovery effectiveness, demonstrating its promising potential for managing complicated infected wounds.