Development of an Albumin–Polymer Bioconjugate via Covalent Conjugation and Supramolecular Interactions

Preexisting serum albumin–polymer bioconjugates have been formed either through covalent conjugation or supramolecular interactions. However, the viability of producing a bioconjugate where both covalent conjugation and supramolecular interactions have been adopted is yet to be explored. In this wor...

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Published inBioconjugate chemistry Vol. 33; no. 2; pp. 321 - 332
Main Authors Xu, You Dan, Tian, Linqing, Lai, Rebecca Yong, Li, Zihao, Procházková, Eliška, Ho, Junming, Stenzel, Martina H
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 16.02.2022
Subjects
Albumin
Conjugation
Covalence
Fatty acids
Molecular Structure
Polymers
Polymers - chemistry
Serum Albumin
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Abstract Preexisting serum albumin–polymer bioconjugates have been formed either through covalent conjugation or supramolecular interactions. However, the viability of producing a bioconjugate where both covalent conjugation and supramolecular interactions have been adopted is yet to be explored. In this work, the noncovalent interaction of two polymers bearing fatty acid-based end-functionalities were compared and the superior binder was carried forward for testing with serum albumin that possessed a polymer conjugated to its Cys34 residue. The studies demonstrated that an albumin–polymer bioconjugate equipped with polymers via both covalent and supramolecular interactions can be successfully achieved.
AbstractList Preexisting serum albumin–polymer bioconjugates have been formed either through covalent conjugation or supramolecular interactions. However, the viability of producing a bioconjugate where both covalent conjugation and supramolecular interactions have been adopted is yet to be explored. In this work, the noncovalent interaction of two polymers bearing fatty acid-based end-functionalities were compared and the superior binder was carried forward for testing with serum albumin that possessed a polymer conjugated to its Cys34 residue. The studies demonstrated that an albumin–polymer bioconjugate equipped with polymers via both covalent and supramolecular interactions can be successfully achieved.
Author Xu, You Dan
Procházková, Eliška
Ho, Junming
Stenzel, Martina H
Li, Zihao
Lai, Rebecca Yong
Tian, Linqing
AuthorAffiliation The Czech Academy of Sciences
Institute of Organic Chemistry and Biochemistry
School of Chemistry
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  surname: Stenzel
  fullname: Stenzel, Martina H
  email: m.stenzel@unsw.edu.au
  organization: School of Chemistry
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Snippet Preexisting serum albumin–polymer bioconjugates have been formed either through covalent conjugation or supramolecular interactions. However, the viability of...
Preexisting serum albumin-polymer bioconjugates have been formed either through covalent conjugation or supramolecular interactions. However, the viability of...
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SubjectTerms Albumin
Conjugation
Covalence
Fatty acids
Molecular Structure
Polymers
Polymers - chemistry
Serum Albumin
Title Development of an Albumin–Polymer Bioconjugate via Covalent Conjugation and Supramolecular Interactions
URI http://dx.doi.org/10.1021/acs.bioconjchem.1c00536
https://www.ncbi.nlm.nih.gov/pubmed/35057618
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