Development of an Albumin–Polymer Bioconjugate via Covalent Conjugation and Supramolecular Interactions

Preexisting serum albumin–polymer bioconjugates have been formed either through covalent conjugation or supramolecular interactions. However, the viability of producing a bioconjugate where both covalent conjugation and supramolecular interactions have been adopted is yet to be explored. In this wor...

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Published inBioconjugate chemistry Vol. 33; no. 2; pp. 321 - 332
Main Authors Xu, You Dan, Tian, Linqing, Lai, Rebecca Yong, Li, Zihao, Procházková, Eliška, Ho, Junming, Stenzel, Martina H
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 16.02.2022
Subjects
Albumin
Conjugation
Covalence
Fatty acids
Molecular Structure
Polymers
Polymers - chemistry
Serum Albumin
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Summary:Preexisting serum albumin–polymer bioconjugates have been formed either through covalent conjugation or supramolecular interactions. However, the viability of producing a bioconjugate where both covalent conjugation and supramolecular interactions have been adopted is yet to be explored. In this work, the noncovalent interaction of two polymers bearing fatty acid-based end-functionalities were compared and the superior binder was carried forward for testing with serum albumin that possessed a polymer conjugated to its Cys34 residue. The studies demonstrated that an albumin–polymer bioconjugate equipped with polymers via both covalent and supramolecular interactions can be successfully achieved.
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ISSN:1043-1802
1520-4812
DOI:10.1021/acs.bioconjchem.1c00536