Surface Multifunctionalization of Inert Ceramic Implants by Calcium Phosphate Biomimetic Coating Doped with Nanoparticles Encapsulating Antibiotics
Aseptic loosening and periprosthetic infections are complications that can occur at the interface between inert ceramic implants and natural body tissues. Therefore, the need for novel materials with antibacterial properties to prevent implant-related infection is evident. This study proposes multif...
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Published in | ACS applied materials & interfaces Vol. 15; no. 17; pp. 21699 - 21718 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
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United States
American Chemical Society
03.05.2023
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Abstract | Aseptic loosening and periprosthetic infections are complications that can occur at the interface between inert ceramic implants and natural body tissues. Therefore, the need for novel materials with antibacterial properties to prevent implant-related infection is evident. This study proposes multifunctionalizing the inert ceramic implant surface by biomimetic calcium phosphate (CaP) coating decorated with antibiotic-loaded nanoparticles for bioactivity enhancement and antibacterial effect. This study aimed to coat zirconium dioxide (ZrO2) substrates with a bioactive CaP-layer containing drug-loaded degradable polymer nanoparticles (NPs). The NPs were loaded with two antibiotics, gentamicin or bacitracin. The immobilization of NPs happened by two deposition methods: coprecipitation and drop-casting. X-ray diffraction (XRD), scanning electron microscopy (SEM), and cross-section analyses were used to characterize the coatings. MG-63 osteoblast-like cells and human mesenchymal stem cells (hMSC) were chosen for in vitro tests. Antibacterial activity was assessed with S. aureus and E. coli. The coprecipitation method allowed for a favorable homogeneous distribution of the NPs within the CaP coating. The CaP coating was constituted of hydroxyapatite and octacalcium phosphate; its thickness was 3.8 ± 1 μm with cavities of around 1 μm suitable for hosting NPs with a size of 200 nm. Antibiotics were released from the coatings in a controlled manner for 1 month. The cell culture study has confirmed the excellent behavior of the coprecipitated coating, showing cytocompatibility and a homogeneous distribution of the cells on the coated surfaces. The increase in alkaline phosphatase activity showed osteogenic differentiation. The materials were found to inhibit the growth of bacteria. Newly developed coatings with antibacterial and bioactive properties are promising candidates to prevent peri-implant infectious bone diseases. |
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AbstractList | Aseptic loosening and periprosthetic infections are complications that can occur at the interface between inert ceramic implants and natural body tissues. Therefore, the need for novel materials with antibacterial properties to prevent implant-related infection is evident. This study proposes multifunctionalizing the inert ceramic implant surface by biomimetic calcium phosphate (CaP) coating decorated with antibiotic-loaded nanoparticles for bioactivity enhancement and antibacterial effect. This study aimed to coat zirconium dioxide (ZrO2) substrates with a bioactive CaP-layer containing drug-loaded degradable polymer nanoparticles (NPs). The NPs were loaded with two antibiotics, gentamicin or bacitracin. The immobilization of NPs happened by two deposition methods: coprecipitation and drop-casting. X-ray diffraction (XRD), scanning electron microscopy (SEM), and cross-section analyses were used to characterize the coatings. MG-63 osteoblast-like cells and human mesenchymal stem cells (hMSC) were chosen for in vitro tests. Antibacterial activity was assessed with S. aureus and E. coli. The coprecipitation method allowed for a favorable homogeneous distribution of the NPs within the CaP coating. The CaP coating was constituted of hydroxyapatite and octacalcium phosphate; its thickness was 3.8 ± 1 μm with cavities of around 1 μm suitable for hosting NPs with a size of 200 nm. Antibiotics were released from the coatings in a controlled manner for 1 month. The cell culture study has confirmed the excellent behavior of the coprecipitated coating, showing cytocompatibility and a homogeneous distribution of the cells on the coated surfaces. The increase in alkaline phosphatase activity showed osteogenic differentiation. The materials were found to inhibit the growth of bacteria. Newly developed coatings with antibacterial and bioactive properties are promising candidates to prevent peri-implant infectious bone diseases. Aseptic loosening and periprosthetic infections are complications that can occur at the interface between inert ceramic implants and natural body tissues. Therefore, the need for novel materials with antibacterial properties to prevent implant-related infection is evident. This study proposes multifunctionalizing the inert ceramic implant surface by biomimetic calcium phosphate (CaP) coating decorated with antibiotic-loaded nanoparticles for bioactivity enhancement and antibacterial effect. This study aimed to coat zirconium dioxide (ZrO ) substrates with a bioactive CaP-layer containing drug-loaded degradable polymer nanoparticles (NPs). The NPs were loaded with two antibiotics, gentamicin or bacitracin. The immobilization of NPs happened by two deposition methods: coprecipitation and drop-casting. X-ray diffraction (XRD), scanning electron microscopy (SEM), and cross-section analyses were used to characterize the coatings. MG-63 osteoblast-like cells and human mesenchymal stem cells (hMSC) were chosen for tests. Antibacterial activity was assessed with and . The coprecipitation method allowed for a favorable homogeneous distribution of the NPs within the CaP coating. The CaP coating was constituted of hydroxyapatite and octacalcium phosphate; its thickness was 3.8 ± 1 μm with cavities of around 1 μm suitable for hosting NPs with a size of 200 nm. Antibiotics were released from the coatings in a controlled manner for 1 month. The cell culture study has confirmed the excellent behavior of the coprecipitated coating, showing cytocompatibility and a homogeneous distribution of the cells on the coated surfaces. The increase in alkaline phosphatase activity showed osteogenic differentiation. The materials were found to inhibit the growth of bacteria. Newly developed coatings with antibacterial and bioactive properties are promising candidates to prevent peri-implant infectious bone diseases. |
Author | Pamuła, Elżbieta Krok-Borkowicz, Małgorzata Kazek-Kęsik, Alicja Desante, Gaëlle Telle, Rainer Schickle, Karolina Pudełko, Iwona Jacobs, Philipp Nießen, Jonas Gonzalez-Julian, Jesus |
AuthorAffiliation | Department of Restorative Dentistry and Endodontology Department of Biomaterials and Composites, Faculty of Materials Science and Ceramics Institute of Mineral Engineering, Chair of Ceramics Faculty of Chemistry, Silesian University of Technology, Gliwice, Poland and Biotechnology Centre Justus-Liebig-University Giessen Institute of Mineral Engineering, Chair of Glass and Glass-ceramic RWTH Aachen University Silesian University of Technology |
AuthorAffiliation_xml | – name: RWTH Aachen University – name: Institute of Mineral Engineering, Chair of Glass and Glass-ceramic – name: Institute of Mineral Engineering, Chair of Ceramics – name: Faculty of Chemistry, Silesian University of Technology, Gliwice, Poland and Biotechnology Centre – name: Department of Restorative Dentistry and Endodontology – name: Silesian University of Technology – name: Department of Biomaterials and Composites, Faculty of Materials Science and Ceramics – name: Justus-Liebig-University Giessen |
Author_xml | – sequence: 1 givenname: Gaëlle orcidid: 0000-0001-6340-5126 surname: Desante fullname: Desante, Gaëlle email: desante@ghi.rwth-aachen.de organization: Institute of Mineral Engineering, Chair of Ceramics – sequence: 2 givenname: Iwona orcidid: 0000-0002-1024-9374 surname: Pudełko fullname: Pudełko, Iwona email: ipudelko@agh.edu.pl organization: Department of Biomaterials and Composites, Faculty of Materials Science and Ceramics – sequence: 3 givenname: Małgorzata surname: Krok-Borkowicz fullname: Krok-Borkowicz, Małgorzata organization: Department of Biomaterials and Composites, Faculty of Materials Science and Ceramics – sequence: 4 givenname: Elżbieta surname: Pamuła fullname: Pamuła, Elżbieta organization: Department of Biomaterials and Composites, Faculty of Materials Science and Ceramics – sequence: 5 givenname: Philipp surname: Jacobs fullname: Jacobs, Philipp organization: RWTH Aachen University – sequence: 6 givenname: Alicja orcidid: 0000-0001-9971-7279 surname: Kazek-Kęsik fullname: Kazek-Kęsik, Alicja organization: Silesian University of Technology – sequence: 7 givenname: Jonas surname: Nießen fullname: Nießen, Jonas organization: Institute of Mineral Engineering, Chair of Ceramics – sequence: 8 givenname: Rainer surname: Telle fullname: Telle, Rainer organization: Institute of Mineral Engineering, Chair of Ceramics – sequence: 9 givenname: Jesus orcidid: 0000-0002-4217-8419 surname: Gonzalez-Julian fullname: Gonzalez-Julian, Jesus organization: Institute of Mineral Engineering, Chair of Ceramics – sequence: 10 givenname: Karolina orcidid: 0000-0003-0944-6917 surname: Schickle fullname: Schickle, Karolina organization: Justus-Liebig-University Giessen |
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SubjectTerms | Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Biomimetics Calcium Phosphates - chemistry Calcium Phosphates - pharmacology Ceramics - pharmacology Coated Materials, Biocompatible - chemistry Coated Materials, Biocompatible - pharmacology Escherichia coli Humans Nanoparticles Osteogenesis Staphylococcus aureus Surface Properties Surfaces, Interfaces, and Applications Titanium - chemistry |
Title | Surface Multifunctionalization of Inert Ceramic Implants by Calcium Phosphate Biomimetic Coating Doped with Nanoparticles Encapsulating Antibiotics |
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