Assembly of Metal–Phenolic/Catecholamine Networks for Synergistically Anti-Inflammatory, Antimicrobial, and Anticoagulant Coatings

• Published in: ACS applied materials & interfaces Vol. 10; no. 47; pp. 40844 - 40853
• Main Authors: Li, Xiangyang, Gao, Peng, Tan, Jianying, Xiong, Kaiqin, Maitz, Manfred F, Pan, Changjiang, Wu, Hongkai, Chen, Yin, Yang, Zhilu, Huang, Nan
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 28.11.2018
• Subjects: Animals; Anti-Inflammatory Agents - pharmacology; Anticoagulants - pharmacology; Catalysis; Catecholamines - pharmacology; Coated Materials, Biocompatible - pharmacology; Drug Synergism; Escherichia coli - drug effects; Free Radical Scavengers - pharmacology; Human Umbilical Vein Endothelial Cells - drug effects; Humans; Interleukin-6 - metabolism; Metals - chemistry; Mice; Microbial Sensitivity Tests; Nitric Oxide - metabolism; Phenols - chemistry; Rabbits; Rats, Sprague-Dawley; Staphylococcus aureus - drug effects; Thrombosis - pathology; Tumor Necrosis Factor-alpha - metabolism; self-assembly; antimicrobial; surface functionalization; anticoagulation; metal−phenolic networks; catalysis; anti-inflammation

The development of a facile and versatile strategy to endow surfaces with synergistically anti-inflammatory, antimicrobial, and anticoagulant functions is of particular significance for blood-contacting biomaterials and medical devices. In this work, we report a simple and environmentally friendly “...