Assembly of Metal–Phenolic/Catecholamine Networks for Synergistically Anti-Inflammatory, Antimicrobial, and Anticoagulant Coatings

• Published in: ACS applied materials & interfaces Vol. 10; no. 47; pp. 40844 - 40853
• Main Authors: Li, Xiangyang, Gao, Peng, Tan, Jianying, Xiong, Kaiqin, Maitz, Manfred F, Pan, Changjiang, Wu, Hongkai, Chen, Yin, Yang, Zhilu, Huang, Nan
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 28.11.2018
• Subjects: Animals; Anti-Inflammatory Agents - pharmacology; Anticoagulants - pharmacology; Catalysis; Catecholamines - pharmacology; Coated Materials, Biocompatible - pharmacology; Drug Synergism; Escherichia coli - drug effects; Free Radical Scavengers - pharmacology; Human Umbilical Vein Endothelial Cells - drug effects; Humans; Interleukin-6 - metabolism; Metals - chemistry; Mice; Microbial Sensitivity Tests; Nitric Oxide - metabolism; Phenols - chemistry; Rabbits; Rats, Sprague-Dawley; Staphylococcus aureus - drug effects; Thrombosis - pathology; Tumor Necrosis Factor-alpha - metabolism; self-assembly; antimicrobial; surface functionalization; anticoagulation; metal−phenolic networks; catalysis; anti-inflammation
• ISSN: 1944-8244; 1944-8252
• DOI: 10.1021/acsami.8b14409

The development of a facile and versatile strategy to endow surfaces with synergistically anti-inflammatory, antimicrobial, and anticoagulant functions is of particular significance for blood-contacting biomaterials and medical devices. In this work, we report a simple and environmentally friendly “one-pot” method inspired by byssal cuticle chemistry, namely, [Fe­(dopa)3] coordination chemistry for assembly of copper ions (Cu2+) and plant polyphenol (tannic acid)/catecholamine (dopamine or norepinephrine) to form metal–phenolic/catecholamine network-based coatings. This one-pot method enabled us to easily develop a multifunctional surface based on the combination of the characteristic functions of metal ions and plant polyphenol or catecholamine. The residual phenolic hydroxyl groups on the coatings imparted the modified surface with excellent antioxidant and anti-inflammatory functions. The robust chelation of copper ions to the metal–phenolic/catecholamine networks provided not only durable antibacterial property but also glutathione peroxidase like catalytic capability to continuously and controllably produce antithrombotic nitric oxide by catalyzing endogenous S-nitrothiol. The biological functions of such coatings could be well regulated by adjusting the ratios of the feed concentration of Cu2+ ions to plant polyphenol or catecholamine. We envision that our simple, multifunctional, and bioinspired coating strategy can hold great application promise for bioengineering blood-contacting devices.