Eliminating Heat Injury of Zeolite in Hemostasis via Thermal Conductivity of Graphene Sponge

Thermal release of zeolite is conducive in hemostasis, but losing control will cause serious burns. How to balance the advantages and disadvantages is a challenge. Herein, a zeolite/cross-linked graphene sponge (Z-CGS) was design to break through this challenge. The CGS managed the heat release of z...

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Published inACS applied materials & interfaces Vol. 11; no. 27; pp. 23848 - 23857
Main Authors Liang, Yuping, Xu, Congcong, Liu, Fang, Du, Shiyu, Li, Guofeng, Wang, Xing
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 10.07.2019
Subjects
Animals
Graphite - chemistry
Graphite - pharmacology
Heat Stress Disorders - prevention & control
Hemorrhage - drug therapy
Hemostasis - drug effects
Hemostatics - chemistry
Hemostatics - pharmacology
Rats
Rats, Sprague-Dawley
Thermal Conductivity
Zeolites - chemistry
Zeolites - pharmacology
zeolite
thermal conduction
hemostasis
composite
graphene
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Summary:Thermal release of zeolite is conducive in hemostasis, but losing control will cause serious burns. How to balance the advantages and disadvantages is a challenge. Herein, a zeolite/cross-linked graphene sponge (Z-CGS) was design to break through this challenge. The CGS managed the heat release of zeolite by thermal conduction of graphene. Infrared thermal imager demonstrated the mild exothermic process and good thermal conductivity of the optimized Z-CGS. It controlled wound temperature below 42 °C effectively, as compared to 70 °C of naked zeolite. Blood clotting index further confirmed the contribution of thermal stimulation in Z-CGS. On the synergy of thermal and charge stimulations of zeolite, as well as physical adsorption of CGS, Z-CGS achieved outstanding hemostatic performance. Bleeding was stopped within 69 s in rat artery injury model, faster than that of the Quikclot Combat Gauze. Additionally, cytotoxicity assay and pathological analysis highlighted its biocompatibility. Z-CGS, therefore, was an outstanding composite of combining advantages of zeolite and graphene, while getting rid of the shortcomings of the basic unit. The thermal conductibility of graphene renews an avenue for the safe and highly efficient use of zeolite in hemostasis.
ISSN:1944-8244
1944-8252
DOI:10.1021/acsami.9b04956