A chemoenzymatic synthesis of leukotriene B4
A total synthesis of leukotriene B4 (1) is accomplished by the assembly of the key chirons 2 and 3, which are prepared via enzymatic methods.
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| Published in | Journal of organic chemistry Vol. 51; no. 8; pp. 1253 - 1258 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
WASHINGTON
American Chemical Society
01.04.1986
Amer Chemical Soc |
| Subjects | |
| Online Access | Get full text |
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| Abstract | A total synthesis of leukotriene B4 (1) is accomplished by the assembly of the key chirons 2 and 3, which are prepared via enzymatic methods. |
|---|---|
| AbstractList | A total synthesis of leukotriene B4 (1) is accomplished by the assembly of the key chirons 2 and 3, which are prepared via enzymatic methods. |
| Author | Han, Chao Qi DiTullio, Dennis Wang, Yi Fong Sih, Charles J |
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| Keywords | Stereochemistry Arachidonic acid derivatives Leucotriene B4 Hemisynthesis |
| Language | English |
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| PublicationTitle | Journal of organic chemistry |
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| PublicationYear | 1986 |
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| References | SIH CJ (WOS:A1986A983000016.12) 1976 TAKAISHI, Y (WOS:A1982PV19400002) 1982; 23 NICOLAOU, KC (WOS:A1984SV60800024) 1984; 106 BORGEAT, P (WOS:A1981KZ43700001) 1981; 24 COLLINS JC (WOS:A1986A983000016.5) 1958; 30 CHEN, CS (WOS:A1982PU95400064) 1982; 104 HUTCHINSON AWJ (WOS:A1986A983000016.7) 1981; 74 ZAMBONI, R (WOS:A1982NU20500007) 1982; 23 SIH CJ (WOS:A1986A983000016.13) 1983; 25 SIH, CJ (WOS:A1984TH58200003) 1984; 23 GOETZL, EJ (WOS:A1980KJ52700028) 1980; 303 ROKACH, J (WOS:A1985AEH8100005) 1985; 18 BORGEAT, P (WOS:A1979GU03700017) 1979; 254 BAILEY, DM (WOS:A1982PG15000021) 1982; 17 SEEBACH, D (WOS:A1975V343800018) 1975; 40 |
| References_xml | – volume: 17 start-page: 203 year: 1982 ident: WOS:A1982PG15000021 article-title: LIPOXYGENASE AND THE RELATED ARACHIDONIC-ACID METABOLITES publication-title: ANNUAL REPORTS IN MEDICINAL CHEMISTRY contributor: fullname: BAILEY, DM – volume: 254 start-page: 2643 year: 1979 ident: WOS:A1979GU03700017 article-title: TRANSFORMATION OF ARACHIDONIC-ACID BY RABBIT POLYMORPHONUCLEAR LEUKOCYTES - FORMATION OF A NOVEL DIHYDROXYEICOSATETRAENOIC ACID publication-title: JOURNAL OF BIOLOGICAL CHEMISTRY contributor: fullname: BORGEAT, P – volume: 23 start-page: 570 year: 1984 ident: WOS:A1984TH58200003 article-title: MICROBIAL ASYMMETRIC CATALYSIS - ENANTIOSELECTIVE REDUCTION OF KETONES publication-title: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION contributor: fullname: SIH, CJ – volume: 24 start-page: 121 year: 1981 ident: WOS:A1981KZ43700001 article-title: LEUKOTRIENES - A MAJOR STEP IN THE UNDERSTANDING OF IMMEDIATE HYPERSENSITIVITY REACTIONS publication-title: JOURNAL OF MEDICINAL CHEMISTRY contributor: fullname: BORGEAT, P – volume: 303 start-page: 822 year: 1980 ident: WOS:A1980KJ52700028 article-title: MEDIATORS OF IMMEDIATE HYPERSENSITIVITY DERIVED FROM ARACHIDONIC-ACID publication-title: NEW ENGLAND JOURNAL OF MEDICINE contributor: fullname: GOETZL, EJ – volume: 106 start-page: 3548 year: 1984 ident: WOS:A1984SV60800024 article-title: A GENERAL AND STEREOCONTROLLED TOTAL SYNTHESIS OF LEUKOTRIENE-B4 AND ANALOGS publication-title: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY contributor: fullname: NICOLAOU, KC – volume: 40 start-page: 231 year: 1975 ident: WOS:A1975V343800018 article-title: GENERATION AND SYNTHETIC APPLICATIONS OF 2-LITHIO-1,3-DITHIANES publication-title: JOURNAL OF ORGANIC CHEMISTRY contributor: fullname: SEEBACH, D – volume: 18 start-page: 87 year: 1985 ident: WOS:A1985AEH8100005 article-title: SYNTHESIS OF LEUKOTRIENES AND LIPOXYGENASE PRODUCTS publication-title: ACCOUNTS OF CHEMICAL RESEARCH contributor: fullname: ROKACH, J – start-page: CH3 year: 1976 ident: WOS:A1986A983000016.12 publication-title: APPLICATIONS BIOCH 1 contributor: fullname: SIH CJ – volume: 74 start-page: 831 year: 1981 ident: WOS:A1986A983000016.7 publication-title: ROY SOC MED INT CONG contributor: fullname: HUTCHINSON AWJ – volume: 104 start-page: 7294 year: 1982 ident: WOS:A1982PU95400064 article-title: QUANTITATIVE-ANALYSES OF BIOCHEMICAL KINETIC RESOLUTIONS OF ENANTIOMERS publication-title: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY contributor: fullname: CHEN, CS – volume: 25 start-page: 215 year: 1983 ident: WOS:A1986A983000016.13 publication-title: BASIC LIFE SCI contributor: fullname: SIH CJ – volume: 23 start-page: 5489 year: 1982 ident: WOS:A1982PV19400002 article-title: BIFUNCTIONAL CHIRAL SYNTHONS VIA MICROBIOLOGICAL METHODS .2. OPTICALLY-ACTIVE ALPHA-HYDROXY ALDEHYDES publication-title: TETRAHEDRON LETTERS contributor: fullname: TAKAISHI, Y – volume: 30 start-page: 3363 year: 1958 ident: WOS:A1986A983000016.5 publication-title: TETRAHEDRON LETT contributor: fullname: COLLINS JC – volume: 23 start-page: 2631 year: 1982 ident: WOS:A1982NU20500007 article-title: SIMPLE EFFICIENT SYNTHESIS OF LTB4 AND 12-EPI-LTB4 publication-title: TETRAHEDRON LETTERS contributor: fullname: ZAMBONI, R |
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| Snippet | A total synthesis of leukotriene B4 (1) is accomplished by the assembly of the key chirons 2 and 3, which are prepared via enzymatic methods. |
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| SubjectTerms | Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology Chemistry Chemistry, Organic Fundamental and applied biological sciences. Psychology Methods. Procedures. Technologies Physical Sciences Science & Technology |
| Title | A chemoenzymatic synthesis of leukotriene B4 |
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