Specific Modification with TPGS and Drug Loading of Cyclodextrin Polyrotaxanes and the Enhanced Antitumor Activity Study in Vitro and in Vivo

• Published in: ACS applied materials & interfaces Vol. 11; no. 50; pp. 46427 - 46436
• Main Authors: Zhang, Yi, Zhou, Qiaoqiao, Jia, Shuxin, Lin, Kunpeng, Fan, Guangfang, Yuan, Jintao, Yu, Shuling, Shi, Jiahua
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 18.12.2019
• Subjects: Animals; Anticarcinogenic Agents - chemistry; Anticarcinogenic Agents - pharmacology; Camptothecin - analogs & derivatives; Camptothecin - chemistry; Camptothecin - pharmacology; Cell Line, Tumor; Cellulose - chemistry; Cellulose - pharmacology; Cyclodextrins - chemistry; Cyclodextrins - pharmacology; Drug Delivery Systems; Humans; Mice; Nanoparticles - chemistry; Neoplasms - drug therapy; Neoplasms - pathology; Rotaxanes - chemistry; Rotaxanes - pharmacology; Vitamin E - chemistry; Vitamin E - pharmacology; Xenograft Model Antitumor Assays; specificity; synergism therapy; polyrotaxane; drug carrier; TPGS
• ISSN: 1944-8244; 1944-8252
• DOI: 10.1021/acsami.9b14075

A kind of specific cyclodextrin polyrotaxanes (PRs) drug delivery system was developed for an effective drug delivery and enhancing antitumor effect. In this work, we prepared the PR by using α-CD derivatives and dicarboxyl-PEG (M n = 4200) self-assembling and end-capping with β-CD derivatives. Then, we chose d-a-Tocopheryl polyethylene glycol 1000 succinate (TPGS) with an antitumor effect to modify the PR. The modified PRs have a certain anticancer effect and can assist the anticancer drug to treat cancer. The 10-hydroxycamptothecin (HCPT) was combined to the specific PRs by covalent bonds to prepare drug-loaded specificity PRs (PR-TPGS-HCPT). The enhanced antitumor activities of PR-TPGS-HCPT were studied by in vitro and in vivo experiments, and the experiment results proved that the TPGS could effectively assist the drug to treat cancer and prolong the lifetime of the tumor-bearing mice. Therefore, this research provides a promising drug-loaded material for the cancer treatment and the specific water-soluble PRs will have potential applications in the biomedical field.