Designer Structures Assembled from Modular DNA Superbricks

Self-assembled DNA structures hold great application potentials in many fields. The DNA structure of a specific feature, however, generally requires a distinct set of DNA strands with unique sequences, which is costly and error-prone. Herein, we expanded the modularity of DNA bricks to assemble a nu...

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Bibliographic Details
Published inACS applied bio materials Vol. 3; no. 5; pp. 2850 - 2853
Main Authors Li, Xue, Yang, Donglei, Kou, Bo, Shen, Luyao, Li, Haofei, Wang, Pengfei
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 18.05.2020
Subjects
DNA self-assembly
DNA bricks
modularity
DNA lattices
cost-effective
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Summary:Self-assembled DNA structures hold great application potentials in many fields. The DNA structure of a specific feature, however, generally requires a distinct set of DNA strands with unique sequences, which is costly and error-prone. Herein, we expanded the modularity of DNA bricks to assemble a number of DNA structures including objects and lattices from the same set of DNA strands. We designed DNA superbricks composed of ∼200 conventional DNA bricks of 52 nucleotides. By modularly programming the sticky interactions between DNA superbricks, we have successfully assembled seven DNA structures of designer features including DNA objects and one-dimensional and two-dimensional DNA brick lattices.
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ISSN:2576-6422
2576-6422
DOI:10.1021/acsabm.9b01046