Naringin@Metal–Organic Framework as a Multifunctional Bioplatform

Naringin, a natural product, can be used as a therapeutic agent due to its low systemic toxicity and negligible adverse effect. However, due to its hydrophobic nature and thereby low solubility, high-dose treatment is required when used for human therapy. Herein, we demonstrate the employment of a m...

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Published inACS applied materials & interfaces Vol. 15; no. 1; pp. 677 - 683
Main Authors Ge, Xueying, Jiang, Fangchao, Wang, Minghui, Chen, Meng, Li, Yiming, Phipps, Joshua, Cai, Jianfeng, Xie, Jin, Ong, Jane, Dubovoy, Viktor, Masters, James G., Pan, Long, Ma, Shengqian
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 11.01.2023
Subjects
Biological and Medical Applications of Materials and Interfaces
Flavanones
Humans
Metal-Organic Frameworks - chemistry
Neoplasms
Solubility
Gram-positive bacteria
naringin
cancer
immune function
metal−organic framework
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Abstract Naringin, a natural product, can be used as a therapeutic agent due to its low systemic toxicity and negligible adverse effect. However, due to its hydrophobic nature and thereby low solubility, high-dose treatment is required when used for human therapy. Herein, we demonstrate the employment of a metal–organic framework (MOF) as a nontoxic loading carrier to encapsulate naringin, and the afforded nairngin@MOF composite can serve as a multifunctional bioplatform capable of treating Gram-positive bacteria and certain cancers by slowly and progressively releasing the encapsulated naringin as well as improving and modulating immune system functions through synergy between naringin and the MOF.
AbstractList Naringin, a natural product, can be used as a therapeutic agent due to its low systemic toxicity and negligible adverse effect. However, due to its hydrophobic nature and thereby low solubility, high-dose treatment is required when used for human therapy. Herein, we demonstrate the employment of a metal–organic framework (MOF) as a nontoxic loading carrier to encapsulate naringin, and the afforded nairngin@MOF composite can serve as a multifunctional bioplatform capable of treating Gram-positive bacteria and certain cancers by slowly and progressively releasing the encapsulated naringin as well as improving and modulating immune system functions through synergy between naringin and the MOF.
Author Li, Yiming
Wang, Minghui
Ma, Shengqian
Xie, Jin
Dubovoy, Viktor
Masters, James G.
Pan, Long
Chen, Meng
Ong, Jane
Jiang, Fangchao
Phipps, Joshua
Ge, Xueying
Cai, Jianfeng
AuthorAffiliation Department of Chemistry
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CitedBy_id crossref_primary_10_3390_foods13040576
crossref_primary_10_1002_smll_202306940
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Keywords Gram-positive bacteria
naringin
cancer
immune function
metal−organic framework
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Snippet Naringin, a natural product, can be used as a therapeutic agent due to its low systemic toxicity and negligible adverse effect. However, due to its hydrophobic...
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SubjectTerms Biological and Medical Applications of Materials and Interfaces
Flavanones
Humans
Metal-Organic Frameworks - chemistry
Neoplasms
Solubility
Title Naringin@Metal–Organic Framework as a Multifunctional Bioplatform
URI http://dx.doi.org/10.1021/acsami.2c19904
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