Naringin@Metal–Organic Framework as a Multifunctional Bioplatform

Naringin, a natural product, can be used as a therapeutic agent due to its low systemic toxicity and negligible adverse effect. However, due to its hydrophobic nature and thereby low solubility, high-dose treatment is required when used for human therapy. Herein, we demonstrate the employment of a m...

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Bibliographic Details
Published inACS applied materials & interfaces Vol. 15; no. 1; pp. 677 - 683
Main Authors Ge, Xueying, Jiang, Fangchao, Wang, Minghui, Chen, Meng, Li, Yiming, Phipps, Joshua, Cai, Jianfeng, Xie, Jin, Ong, Jane, Dubovoy, Viktor, Masters, James G., Pan, Long, Ma, Shengqian
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 11.01.2023
Subjects
Biological and Medical Applications of Materials and Interfaces
Flavanones
Humans
Metal-Organic Frameworks - chemistry
Neoplasms
Solubility
Gram-positive bacteria
naringin
cancer
immune function
metal−organic framework
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Summary:Naringin, a natural product, can be used as a therapeutic agent due to its low systemic toxicity and negligible adverse effect. However, due to its hydrophobic nature and thereby low solubility, high-dose treatment is required when used for human therapy. Herein, we demonstrate the employment of a metal–organic framework (MOF) as a nontoxic loading carrier to encapsulate naringin, and the afforded nairngin@MOF composite can serve as a multifunctional bioplatform capable of treating Gram-positive bacteria and certain cancers by slowly and progressively releasing the encapsulated naringin as well as improving and modulating immune system functions through synergy between naringin and the MOF.
ISSN:1944-8244
1944-8252
DOI:10.1021/acsami.2c19904