Green, pH-Sensitive, Highly Stretchable, and Hydrogen Bond-Dominated Ionogel for Wound Healing Activity

• Published in: ACS applied bio materials Vol. 7; no. 1; pp. 498 - 507
• Main Authors: Zhi, Hui, Wang, Fengya, Zhang, Xiaobo, Cai, Qinxin, Chen, Meng, Shi, Yushu, Feng, Liang
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 15.01.2024
• Subjects: Anthocyanins; Bisphenol A-Glycidyl Methacrylate; Hydrogen Bonding; Hydrogen-Ion Concentration; Wound Healing; anthocyanidin; pH-sensitive; wound dressing; ionogel; hydrogen bond
• ISSN: 2576-6422; 2576-6422
• DOI: 10.1021/acsabm.3c01146

Traditional hydrogel dressings generally have poor mechanical properties and stability when subjected to external stress due to the undesirable chain entanglement structure of their single valence bond compositions. Therefore, it is particularly important to develop a type of gel dressing with good mechanical strength, stability, and environment-friendly monitoring. In this work, a transparent, pH-sensitive, highly stretchable, and biocompatible anthocyanidin ionogel dressing was prepared, realizing green and accurate detection. Attributed to the antibacterial activity of the ionic liquid, the biocompatibility of the pectin, and the ability to scavenge free radicals of the anthocyanidin, the ionogel dressing exhibited excellent re-epithelialization in the 14 day wound healing process. Besides, changes in pH values monitoring of the ionogel over 3 days coincided with normal wound exudate. The obtained ionogel also showed good water retention, swelling properties, mechanical stretchability, and 5 week stability, illustrating great potential in wound dressings.