Versatile Bioactive Glass/Zeolitic Imidazolate Framework-8-Based Skin Scaffolds toward High-Performance Wound Healing

• Published in: ACS applied materials & interfaces Vol. 16; no. 7; pp. 8228 - 8237
• Main Authors: Hou, Yongchun, Xu, Xiaowei, Zhou, Yaqin, Li, Qing, Zhu, Liangliang, Liu, Chang, Chen, Su, Pang, Jie
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 21.02.2024
• Subjects: Anti-Bacterial Agents - pharmacology; Biological and Medical Applications of Materials and Interfaces; Escherichia coli; Polyesters - pharmacology; Staphylococcus aureus; Tissue Scaffolds; Wound Healing; wound healing; bioactive glass; microfluidic electrospinning; zeolitic imidazolate framework-8; fiber scaffolds
• ISSN: 1944-8244; 1944-8252
• DOI: 10.1021/acsami.3c14529

Designing a novel biomaterial for wound healing is based on biocompatibility and excellent mechanical strength. In this study, bioactive glass (BG) and zeolitic imidazolate framework-8 (ZIF-8) have been incorporated into poly­(ε-caprolactone)/poly­(vinyl alcohol) (PCL/PVA) composite skin scaffolds via microfluidic electrospinning. Interestingly, the addition of ZIF-8 further strengthens the BG stability and demonstrates better antibacterial effects. Utilizing the slow release of Zn, Ca, and Si ions, it also significantly promotes growth factor expression and skin regeneration. In addition, it is further demonstrated by in vitro and in vivo studies that the prepared composite skin scaffolds possess excellent biocompatibility, antibacterial capabilities, and mechanical properties. The prepared BG/ZIF-8-loaded scaffold possesses high tensile strength (26 MPa) and excellent antibacterial properties (achieves 89.64 and 78.8% inhibition of E. coli and S. aureus, respectively), and cell viability increased by 51.2%. More importantly, the wound shrinkage of the BG/ZIF-8-loaded scaffold is better than that of an unloaded scaffold, and the shrinkage rates of PCL/PVA@BG/ZIF-8­(1 wt %) group is 95% with 2.2 mm granulation growth thickness within 12 days. Thus, the composite skin scaffold loaded with BG/ZIF-8 prepared by microfluidic electrospinning provides a new perspective for accelerating wound healing and is a potential novel therapeutic strategy for efficient wound healing.