Determination and Evaluation of Acid Dissociation Constants of Some Substituted 2-Aminobenzothiazole Derivatives

The acid dissociation constants of some 4- and/or 6-substituted 2-aminobenzothiazole and 4-substituted thiazole derivatives were determined spectroscopically. With the exception of a few, the first protonation was found to occur on the amino group. In some molecules where prototropic tautomerism is...

Full description

Saved in:
Bibliographic Details
Published inJournal of chemical and engineering data Vol. 53; no. 2; pp. 422 - 426
Main Authors Öğretir, Cemil, Demirayak, Şeref, Tay, N. Funda, Duran, M
Format Journal Article
LanguageEnglish
Published Washington, DC American Chemical Society 01.02.2008
Subjects
Chemistry
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings
Organic chemistry
Preparations and properties
Dissociation constant
Protonation
Chemical properties
Benzothiazole derivatives
Thiazole derivatives
Online AccessGet full text

Cover

More Information
Summary:The acid dissociation constants of some 4- and/or 6-substituted 2-aminobenzothiazole and 4-substituted thiazole derivatives were determined spectroscopically. With the exception of a few, the first protonation was found to occur on the amino group. In some molecules where prototropic tautomerism is possible, a change-over in the protonation mechanism was observed. The first protonation under these circumstances was found to occur on the imino nitrogen atom. The second protonation takes place on the thiazole ring nitrogen atom.
Bibliography:istex:0CDEAC08A841D592D51A14BA9F1A85E55CFDB20F
The financial support of the Board of Scientific Research Projects of Eskisehir Osmangazi University throughout this work with Research Project 200419010 is gratefully acknowledged.
ark:/67375/TPS-LT4RL8T4-L
ISSN:0021-9568
1520-5134
DOI:10.1021/je700515k