The Development of a Scalable, Chemoselective Nitro Reduction
We have demonstrated a scalable chemoselective reduction of a nitro functional group in the presence of an aryl imine using (NH4)2S/EtOH or hydrogenation (Sponge Nickel) to afford the corresponding amino-imines in moderate to excellent yields. Other reducible groups such as aryl halides, styryl olef...
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Published in | Organic process research & development Vol. 16; no. 10; pp. 1665 - 1668 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
WASHINGTON
American Chemical Society
19.10.2012
Amer Chemical Soc |
Subjects | |
Online Access | Get full text |
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Summary: | We have demonstrated a scalable chemoselective reduction of a nitro functional group in the presence of an aryl imine using (NH4)2S/EtOH or hydrogenation (Sponge Nickel) to afford the corresponding amino-imines in moderate to excellent yields. Other reducible groups such as aryl halides, styryl olefins, and ether linkages survived as well. |
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ISSN: | 1083-6160 1520-586X |
DOI: | 10.1021/op3002239 |