Coevolution of Atomic Resolution and Whole-Brain Imaging for Tau Neurofibrillary Tangles

Neurofibrillary tangle (NFT) imaging methods at the distinct scales of atomic and whole-brain resolutions have coevolved rapidly. Linking these two areas of research provides insight into how and why certain tau radiotracers, using positron emission tomography (PET), bind selectively to certain morp...

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Published inACS chemical neuroscience Vol. 11; no. 17; pp. 2513 - 2522
Main Authors Dalton, Raeann M, Krishnan, Hema S, Parker, Victoria S, Catanese, Mary C, Hooker, Jacob M
Format Journal Article
LanguageEnglish
Published American Chemical Society 02.09.2020
Subjects
tau proteins
Alzheimer’s disease
positron emission tomography
neuroimaging agents
neurofibrillary tangles
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Summary:Neurofibrillary tangle (NFT) imaging methods at the distinct scales of atomic and whole-brain resolutions have coevolved rapidly. Linking these two areas of research provides insight into how and why certain tau radiotracers, using positron emission tomography (PET), bind selectively to certain morphological forms of the NFT fibril. In this Review, a brief history and background for each research area is presented leading to a summary of the current state of knowledge, with a synopsis of PET NFT radiotracers and an outlook for near-term research efforts. The continued integration of information provided at the level of each of these scales of resolution will catalyze the next generation of clinical imaging technique development and enhance our interpretations of them.
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ISSN:1948-7193
1948-7193
DOI:10.1021/acschemneuro.0c00426