Antibacterial Pentacyclic Polyketides from a Soil-Derived Streptomyces

Nine new pentacyclic polyketides, fasamycins G–K (1–5) and formicamycins N–Q (6–9), along with 10 known analogues (10–19), were isolated from a rhizospheric soil-derived Streptomyces sp. KIB-1414. Their structures and absolute configurations were elucidated by interpretation of NMR and HRMS data and...

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Published inJournal of natural products (Washington, D.C.) Vol. 83; no. 6; pp. 1919 - 1924
Main Authors Yuan, Jie, Wang, Li, Ren, Jinqiu, Huang, Jian-Ping, Yu, Mingming, Tang, Jun, Yan, Yijun, Yang, Jing, Huang, Sheng-Xiong
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society and American Society of Pharmacognosy 26.06.2020
Amer Chemical Soc
Subjects
Chemistry, Medicinal
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Plant Sciences
Science & Technology
BETA-LACTAM RESISTANCE
CIRCUMVENTORS
RESISTANT STAPHYLOCOCCUS-AUREUS
NAPHTHACEMYCINS
MRSA
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Summary:Nine new pentacyclic polyketides, fasamycins G–K (1–5) and formicamycins N–Q (6–9), along with 10 known analogues (10–19), were isolated from a rhizospheric soil-derived Streptomyces sp. KIB-1414. Their structures and absolute configurations were elucidated by interpretation of NMR and HRMS data and comparisons of CD data. The compounds were active against methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus aureus, Bacillus subtilis, and Escherichia coli strains, with MIC values ranging from 0.20 to 50.00 μg/mL.
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ISSN:0163-3864
1520-6025
DOI:10.1021/acs.jnatprod.0c00161