Photoresponsive Hydrogen-Bonded Organic Frameworks-Enabled Organic Photoelectrochemical Transistors for Sensitive Bioanalysis

• Published in: Analytical chemistry (Washington) Vol. 96; no. 5; pp. 2135 - 2141
• Main Authors: Yin, Peiying, Li, Zheng, Wu, Qiuhua, Hu, Jin, Chen, Feng-Zao, Chen, Guangxu, Lin, Peng, Han, De-Man, Zhao, Wei-Wei
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 06.02.2024
• Subjects: Benzoic Acid; Deoxyribonucleic acid; DNA; Hydrogen; Hydrogen bonding; MicroRNAs; miRNA; Polyethylene; Ribonucleic acid; RNA; Steric hindrance; Target detection; Transconductance; Transistors
• ISSN: 0003-2700; 1520-6882
• DOI: 10.1021/acs.analchem.3c04875

A facile route for exponential magnification of transconductance (g m) in an organic photoelectrochemical transistor (OPECT) is still lacking. Herein, photoresponsive hydrogen-bonded organic frameworks (PR-HOFs) have been shown to be efficient for g m magnification in a typical poly­(ethylene dioxythiophene):poly­(styrenesulfonate) OPECT. Specifically, 450 nm light stimulation of 1,3,6,8-tetrakis (p-benzoic acid) pyrene (H4TBAPy)-based HOF could efficiently modulate the device characteristics, leading to the considerable g m magnification over 78 times from 0.114 to 8.96 mS at zero V g. In linkage with a DNA nanomachine-assisted steric hindrance amplification strategy, the system was then interfaced with the microRNA-triggered structural DNA evolution toward the sensitive detection of a model target microRNA down to 0.1 fM. This study first reveals HOFs-enabled efficient g m magnification in organic electronics and its application for sensitive biomolecular detection.