Process Intensification for the Continuous Flow Hydrogenation of Ethyl Nicotinate

Here we report a process intensification study for the selective, partial, and full hydrogenation of ethyl nicotinate using a trickle bed reactor for meso-flow transformations (HEL FlowCAT). The process achieved a throughput of 1219 g d–1 (78 g h–1 of product per g of active catalyst) for the partia...

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Bibliographic Details
Published inOrganic process research & development Vol. 18; no. 11; pp. 1560 - 1566
Main Authors Ouchi, Takashi, Battilocchio, Claudio, Hawkins, Joel M., Ley, Steven V.
Format Journal Article
LanguageEnglish
Published American Chemical Society 21.11.2014
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Summary:Here we report a process intensification study for the selective, partial, and full hydrogenation of ethyl nicotinate using a trickle bed reactor for meso-flow transformations (HEL FlowCAT). The process achieved a throughput of 1219 g d–1 (78 g h–1 of product per g of active catalyst) for the partial hydrogenation to ethyl 1,4,5,6-tetrahydropyridine-3-carboxylate, whereas the productivity for the full hydrogenation process reached a 1959 g d–1 of throughput (408 g h–1 of product per g of active catalyst) on this laboratory-scale flow chemistry platform.
ISSN:1083-6160
1520-586X
DOI:10.1021/op500208j