Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals
This review showcases various coupling reagents which have been implemented specifically for large-scale amide synthesis via the condensation of an acid and amine, while highlighting the benefits and drawbacks of each reagent on an industrial scale.
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| Published in | Organic process research & development Vol. 20; no. 2; pp. 140 - 177 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
American Chemical Society
19.02.2016
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| Online Access | Get full text |
| ISSN | 1083-6160 1520-586X |
| DOI | 10.1021/op500305s |
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| Abstract | This review showcases various coupling reagents which have been implemented specifically for large-scale amide synthesis via the condensation of an acid and amine, while highlighting the benefits and drawbacks of each reagent on an industrial scale. |
|---|---|
| AbstractList | This review showcases various coupling reagents which have been implemented specifically for large-scale amide synthesis via the condensation of an acid and amine, while highlighting the benefits and drawbacks of each reagent on an industrial scale. |
| Author | Dunetz, Joshua R Magano, Javier Weisenburger, Gerald A |
| AuthorAffiliation | Process Chemistry Pfizer Worldwide Research & Development Chemical Research & Development Gilead Sciences |
| AuthorAffiliation_xml | – name: Gilead Sciences – name: Chemical Research & Development – name: Pfizer Worldwide Research & Development – name: Process Chemistry |
| Author_xml | – sequence: 1 givenname: Joshua R surname: Dunetz fullname: Dunetz, Joshua R email: Joshua.Dunetz@Gilead.com – sequence: 2 givenname: Javier surname: Magano fullname: Magano, Javier email: Javier.Magano@Pfizer.com – sequence: 3 givenname: Gerald A surname: Weisenburger fullname: Weisenburger, Gerald A email: Gerald.A.Weisenburger@Pfizer.com |
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| Snippet | This review showcases various coupling reagents which have been implemented specifically for large-scale amide synthesis via the condensation of an acid and... |
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| Title | Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals |
| URI | http://dx.doi.org/10.1021/op500305s |
| Volume | 20 |
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