Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals

This review showcases various coupling reagents which have been implemented specifically for large-scale amide synthesis via the condensation of an acid and amine, while highlighting the benefits and drawbacks of each reagent on an industrial scale.

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Bibliographic Details
Published inOrganic process research & development Vol. 20; no. 2; pp. 140 - 177
Main Authors Dunetz, Joshua R, Magano, Javier, Weisenburger, Gerald A
Format Journal Article
LanguageEnglish
Published American Chemical Society 19.02.2016
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Summary:This review showcases various coupling reagents which have been implemented specifically for large-scale amide synthesis via the condensation of an acid and amine, while highlighting the benefits and drawbacks of each reagent on an industrial scale.
ISSN:1083-6160
1520-586X
DOI:10.1021/op500305s