A Novel Dewar-Like Reactor for Maintaining Constant Heat and Enhancing Product Yields during Microwave-Assisted Organic Syntheses

A novel microwave reaction vessel is herein proposed for maintaining constant heat during microwave-assisted organic syntheses. The structure of the vessel is Dewar-like in that it prevents conduction of microwave-generated heat in dielectric substrates into the surroundings. The potential of the do...

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Bibliographic Details
Published inOrganic process research & development Vol. 14; no. 6; pp. 1453 - 1456
Main Authors Horikoshi, Satoshi, Osawa, Atsushi, Suttisawat, Yindee, Abe, Masahiko, Serpone, Nick
Format Journal Article
LanguageEnglish
Published American Chemical Society 19.11.2010
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Summary:A novel microwave reaction vessel is herein proposed for maintaining constant heat during microwave-assisted organic syntheses. The structure of the vessel is Dewar-like in that it prevents conduction of microwave-generated heat in dielectric substrates into the surroundings. The potential of the double-walled vacuum-filled vessel has been examined for the absence of thermal gradients in aqueous media (homogeneous media) and in the synthesis of biphenyl in a nonpolar solvent (heterogeneous media) involving the Suzuki−Miyaura coupling reaction. The efficiency of the microwave-assisted organic synthesis was enhanced significantly (6- to 7-fold) with this double-walled vessel relative to the conventional single-walled reactor vessel currently used in commercial microwave chemical devices.
ISSN:1083-6160
1520-586X
DOI:10.1021/op100181u