Structural Patterns Enhancing the Antibacterial Activity of Metallacarborane-Based Antibiotics

• Published in: Journal of medicinal chemistry Vol. 66; no. 21; pp. 14948 - 14962
• Main Authors: Cebula, Jakub, Fink, Krzysztof, Goldeman, Waldemar, Szermer-Olearnik, Bożena, Nasulewicz-Goldeman, Anna, Psurski, Mateusz, Cuprych, Monika, Kędziora, Anna, Dudek, Bartłomiej, Bugla-Płoskońska, Gabriela, Chaszczewska-Markowska, Monika, Gos, Michalina, Migdał, Paweł, Goszczyński, Tomasz M.
• Format: Journal Article
• Language: English
• Published: American Chemical Society 09.11.2023
• ISSN: 0022-2623; 1520-4804
• DOI: 10.1021/acs.jmedchem.3c01516

Healthcare systems heavily rely on antibiotics to treat bacterial infections, but the widespread presence of multidrug-resistant bacteria puts this strategy in danger. Novel drugs capable of overcoming current resistances are needed if our ability to treat bacterial infections is to be maintained. Boron clusters offer a valuable possibility to create a new class of antibiotics and expand the chemical space of antibiotics beyond conventional carbon-based molecules. In this work, we identified two promising structural patterns providing cobalta bis­(dicarbollide)­(COSAN)-based compounds with potent and selective activity toward Staphylococcus aureus (including clinical strains): introduction of the α-amino acid amide and addition of iodine directly to the metallacarborane cage. Furthermore, we found that proper hydrophilic–lipophilic balance is crucial for the selective activity of the tested compounds toward S. aureus over mammalian cells. The patterns proposed in this paper can be useful in the development of metallacarborane-based antibiotics with potent antibacterial properties and low cytotoxicity.