A Comparison of Commercial Microwave Reactors for Scale-Up within Process Chemistry

Seven commercially available microwave reactors designed for limited scale-up have been investigated using a highly reliable and robust reaction (the Newman−Kwart rearrangement). The use of a single reaction has enabled the comparison to be made across the range of different reactor types and scales...

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Bibliographic Details
Published inOrganic process research & development Vol. 12; no. 1; pp. 30 - 40
Main Authors Moseley, Jonathan D, Lenden, Philip, Lockwood, Mark, Ruda, Katinka, Sherlock, Jon-Paul, Thomson, Anthony D, Gilday, John P
Format Journal Article
LanguageEnglish
Published American Chemical Society 01.01.2008
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Summary:Seven commercially available microwave reactors designed for limited scale-up have been investigated using a highly reliable and robust reaction (the Newman−Kwart rearrangement). The use of a single reaction has enabled the comparison to be made across the range of different reactor types and scales. Overall, all reactors gave reliable scale-up from small scale, and performance equivalent to one another on large scale. A more detailed comparison between them is given in the concluding section.
ISSN:1083-6160
1520-586X
DOI:10.1021/op700186z