Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3,5-difluoro- 6-[3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylglycine (ZK-807834):  A Potent, Selective, and Orally Active Inhibitor of the Blood Coagulation Enzyme Factor Xa

• Published in: Journal of medicinal chemistry Vol. 41; no. 19; pp. 3557 - 3562
• Main Authors: Phillips, Gary B, Buckman, Brad O, Davey, David D, Eagen, Keith A, Guilford, William J, Hinchman, Josephine, Ho, Elena, Koovakkat, Sunil, Liang, Amy, Light, David R, Mohan, Raju, Ng, Howard P, Post, Joseph M, Shaw, Kenneth J, Smith, Dave, Subramanyam, Babu, Sullivan, Mark E, Trinh, Lan, Vergona, Ron, Walters, Janette, White, Kathy, Whitlow, Marc, Wu, Shung, Xu, Wei, Morrissey, Michael M
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 10.09.1998; Amer Chemical Soc
• Subjects: Biological and medical sciences; Blood. Blood coagulation. Reticuloendothelial system; Chemistry, Medicinal; Life Sciences & Biomedicine; Medical sciences; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Science & Technology; THROMBIN; ANTICOAGULANT; Monkey; Coagulation Factor Xa; Non peptide compound; Anticoagulant; Selectivity; Modeling; Pyridine derivatives; Structure activity relation; Molecular model; Primates; Chemical synthesis; Dog; Fissipedia; Carnivora; Serine endopeptidases; Enzyme; Benzene derivatives; Oral administration; Enzyme inhibitor; Inhibitor enzyme complex; Bioavailability; In vitro; Peptidases; In vivo; α-Aminoacid; Vertebrata; Amidine; Mammalia; Animal; Hydrolases; Fluorine Organic compounds; Pharmacokinetics
• ISSN: 0022-2623; 1520-4804
• DOI: 10.1021/jm980280h