Increase of Brain Oxidative Stress in Mild Cognitive Impairment: A Possible Predictor of Alzheimer Disease

• Published in: Archives of neurology (Chicago) Vol. 59; no. 6; pp. 972 - 976
• Main Authors: Praticò, Domenico, Clark, Christopher M, Liun, Feyan, Lee, Virginia Y.-M, Trojanowski, John Q
• Format: Journal Article
• Language: English
• Published: Chicago, IL American Medical Association 01.06.2002
• Subjects: Adult; Aged; Aged, 80 and over; Alzheimer Disease - diagnosis; Alzheimer Disease - metabolism; Alzheimer Disease - psychology; Analysis of Variance; Biological and medical sciences; Brain - metabolism; Cognition Disorders - metabolism; Cognition Disorders - psychology; Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes; Female; Humans; Lipid Peroxidation - physiology; Male; Medical sciences; Middle Aged; Nervous system (semeiology, syndromes); Neurology; Oxidative Stress - physiology; Predictive Value of Tests; Human; Oxidative stress; Nervous system diseases; Prognosis; Cognitive disorder; Alzheimer disease; Central nervous system; Cerebral disorder; Gas chromatography; Central nervous system disease; Evolution; Degenerative disease; Mass spectrometry; Brain (vertebrata)
• ISSN: 0003-9942; 2168-6149; 1538-3687; 2168-6157
• DOI: 10.1001/archneur.59.6.972

BACKGROUND The isoprostane 8,12-iso-iPF2α-VI, a specific marker of in vivo lipid peroxidation, is increased in Alzheimer disease (AD). The pathological changes associated with AD have a long silent phase before the appearance of clinical symptoms. Several studies have shown that AD is preceded by a prodromal phase characterized by mild cognitive impairment (MCI). OBJECTIVE To investigate levels of this biomarker in subjects with MCI. DESIGN AND MAIN OUTCOME MEASURES Using gas chromatography–mass spectrometry analysis, we measured 8,12-iso-iPF2α-VI levels in urine, plasma, and cerebrospinal fluid of patients with AD, subjects with MCI, and cognitively normal elderly subjects. SETTING AND PATIENTS Subjects attending the Memory Disorders Clinic. RESULTS We found significantly higher 8,12-iso-iPF2α-VI levels in cerebrospinal fluid, plasma, and urine of subjects with MCI compared with cognitively normal elderly subjects. CONCLUSIONS These results imply that individuals with MCI have increased brain oxidative damage before the onset of symptomatic dementia. Measurement of this isoprostane may identify a subgroup of patients with MCI with increased lipid peroxidation who are at increased risk to progress to symptomatic AD.Arch Neurol. 2002;59:972-976-->