Metabolism of [14C]Ceftiofur Hydrochloride in Swine after Intramuscular Injections

Twelve mix-breed swine (26.5−42.5 kg) received three intramuscular doses of [14C]ceftiofur hydrochloride at 24 h intervals. Three males and three females received 6.76 ± 0.83 mg of [14C]ceftiofur free acid equivalents (CE)/kg body weight (bw)/day, while three males and three females received 4.41 ±...

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Published inJournal of agricultural and food chemistry Vol. 45; no. 7; pp. 2606 - 2611
Main Authors Beconi-Barker, Maria G, Smith, Evan B, Arnold, Thomas S, Hornish, Rex E, Vidmar, Tom J, Gatchell, Cathy L
Format Journal Article
LanguageEnglish
Published Washington, DC American Chemical Society 16.07.1997
Subjects
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Medical sciences
Pharmacology. Drug treatments
Ceftiofur
Veterinary medicine
Metabolism
Intramuscular administration
Pig
Vertebrata
Antibiotic
Cephalosporin derivatives
Mammalia
Animal
Artiodactyla
Antibacterial agent
Ungulata
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Summary:Twelve mix-breed swine (26.5−42.5 kg) received three intramuscular doses of [14C]ceftiofur hydrochloride at 24 h intervals. Three males and three females received 6.76 ± 0.83 mg of [14C]ceftiofur free acid equivalents (CE)/kg body weight (bw)/day, while three males and three females received 4.41 ± 0.97 mg of CE/kg bw/day. All swine were euthanatized 12 h after the last dose. Most of the 14C-residues (>80%) in tissues were associated with macromolecules. The rest of the 14C-activity corresponded to desfuroylceftiofur (DFC)−cysteine. The type and percentages of metabolites present in the urine of swine were similar to those previously observed for ceftiofur sodium (Gilbertson et al., J. Agric. Food Chem. 1995, 43, 229−234), with DFC−cysteine and DFC-dimer being the major ones. In plasma, the major portion of the 14C-activity (>85%) was associated with macromolecules. DFC−cysteine was the only detectable 14C-component of the macromolecule-free plasma fraction. This study indicated that ceftiofur hydrochloride was absorbed in the same ionic form as ceftiofur sodium, acceding to the same primary metabolite DFC. The type of metabolites present in swine after intramuscular injection were the same, regardless of the salt administered. Keywords: Metabolism; ceftiofur hydrochloride; swine; EXCENEL sterile suspension
Bibliography:ark:/67375/TPS-DPVPFVLN-0
istex:8512121847C45894837DDF606C4F15C3D239C2E3
Abstract published in Advance ACS Abstracts, June 15, 1997.
ISSN:0021-8561
1520-5118
DOI:10.1021/jf970279b