Total Synthesis of Shishijimicin A

The total synthesis of the rare but extremely potent antitumor agent shishijimicin A has been achieved via a convergent strategy involving carboline disaccharide 3 and hydroxy enediyne thioacetate 4.

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Bibliographic Details
Published inJournal of the American Chemical Society Vol. 137; no. 27; pp. 8716 - 8719
Main Authors Nicolaou, K. C, Lu, Zhaoyong, Li, Ruofan, Woods, James R, Sohn, Te-ik
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 15.07.2015
Amer Chemical Soc
Subjects
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Biological Products - chemical synthesis
Biological Products - chemistry
Carbolines - chemical synthesis
Carbolines - chemistry
Chemistry
Chemistry, Multidisciplinary
Disaccharides - chemical synthesis
Disaccharides - chemistry
Enediynes - chemical synthesis
Enediynes - chemistry
Physical Sciences
Science & Technology
Sulfhydryl Compounds - chemical synthesis
Sulfhydryl Compounds - chemistry
ANTITUMOR ANTIBIOTICS
CALICHEAMICIN
DOMAIN
REAGENTS
DNA
CHEMISTRY
GENERATION
CALICHEMICINS
FAMILY
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Summary:The total synthesis of the rare but extremely potent antitumor agent shishijimicin A has been achieved via a convergent strategy involving carboline disaccharide 3 and hydroxy enediyne thioacetate 4.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0002-7863
1520-5126
DOI:10.1021/jacs.5b05575