Snapshots of Fluoride Binding in an Aza Cryptand

Thirty years after the first observation of halide encapsulation by katapinand receptors, the authors have utilized {sup 19}F NMR spectroscopy in conjunction with X-ray crystallography to provide snapshots of fluoride binding in an aza cryptand, 1, over a range of pH values. The results provide defi...

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Bibliographic Details
Published inJournal of the American Chemical Society Vol. 122; no. 8; pp. 1814 - 1815
Main Authors Mason, Susan, Llinares, José M, Morton, Martha, Clifford, Thomas, Bowman-James, Kristin
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 01.03.2000
Subjects
AZAARENES
CHEMICAL BONDS
CRYSTALLOGRAPHY
FLUORINE 19
INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY
NUCLEAR MAGNETIC RESONANCE
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Summary:Thirty years after the first observation of halide encapsulation by katapinand receptors, the authors have utilized {sup 19}F NMR spectroscopy in conjunction with X-ray crystallography to provide snapshots of fluoride binding in an aza cryptand, 1, over a range of pH values. The results provide definitive solution and solid-state evidence for the incorporation of fluoride in the cavity. This is the first study that integrates crystallographic findings with {sup 19}F NMR data as a means of understanding the binding patterns of fluoride as a function of pH.
Bibliography:ark:/67375/TPS-CR5VRCMW-7
istex:70975A234EAFD43E46B3C9D38989E54B697B8B3F
USDOE
FG07-96ER62307
ISSN:0002-7863
1520-5126
DOI:10.1021/ja9939800