Asperemestrins A–D, Emestrin Hybrid Polymers with Bridged Skeletons from the Endophytic Fungus Aspergillus nidulans

Four emestrin hybrid polymers, asperemestrins A–D (1–4, respectively), were isolated from the fungus Aspergillus nidulans. Asperemestrins A–C are the first examples of emestrin–sterigmatocystin heterodimers bearing a 7/5/6/6/5/5/6/6/6 nonacyclic system with a 2,5-diazabicyclo[2.2.2]­octane-3,6-dione...

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Published inOrganic letters Vol. 24; no. 37; pp. 6800 - 6804
Main Authors Li, Qin, Fu, Aimin, Wei, Mengsha, Xiao, Yang, Yin, Jie, Huang, Jianzheng, Li, Xiao-Nian, Tong, Qingyi, Chen, Chunmei, Zhu, Hucheng, Zhang, Yonghui
Format Journal Article
LanguageEnglish
Published American Chemical Society 23.09.2022
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Summary:Four emestrin hybrid polymers, asperemestrins A–D (1–4, respectively), were isolated from the fungus Aspergillus nidulans. Asperemestrins A–C are the first examples of emestrin–sterigmatocystin heterodimers bearing a 7/5/6/6/5/5/6/6/6 nonacyclic system with a 2,5-diazabicyclo[2.2.2]­octane-3,6-dione core, while asperemestrin D features an unprecedented 2,15-dithia-17,19-diazabicyclo[14.2.2]­icosa-4,8-diene-12,18,20-trione core skeleton. Their structures were determined by extensive spectroscopic data, electronic circular dichroism calculations, and single-crystal X-ray diffraction. Asperemestrin B showed moderate cytotoxicity against cancer cell lines, including SU-DHL-2, HEPG2, and HL-60.
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ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.2c02701