Multicompartment Block Polymer Micelles

Multicompartment micelles are an intriguing class of self-assembled aggregates with subdivided solvophobic cores. They have been subject to extensive research in part due to their unique morphological and sequestration properties as a result of multiple distinct chemical environments being in close...

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Bibliographic Details
Published inMacromolecules Vol. 45; no. 1; pp. 2 - 19
Main Authors Moughton, Adam O, Hillmyer, Marc A, Lodge, Timothy P
Format Journal Article
LanguageEnglish
Published Washington, DC American Chemical Society 10.01.2012
Subjects
Applied sciences
drugs
Exact sciences and technology
micelles
nanomaterials
Organic polymers
Physicochemistry of polymers
polymers
Properties and characterization
Solution and gel properties
therapeutics
Linear copolymer
Star copolymer
Terpolymer
Chemical solution
Triblock copolymer
State of the art
Multiblock copolymer
Micellar solution
Micellization
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Summary:Multicompartment micelles are an intriguing class of self-assembled aggregates with subdivided solvophobic cores. They have been subject to extensive research in part due to their unique morphological and sequestration properties as a result of multiple distinct chemical environments being in close proximity within one nanostructure. Multicompartment micelles hold potential for use in various applications that include the therapeutic delivery of multiple incompatible drug payloads. The present Perspective reviews recent achievements in strategies for the synthesis, self-assembly, and morphological control of multicompartment micelles and highlights future challenges and potential applications.
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ISSN:0024-9297
1520-5835
1520-5835
DOI:10.1021/ma201865s