Rh(III)-Catalyzed Oxidative C–H Activation/Domino Annulation of Anilines with 1,3-Diynes: A Rapid Access to Blue-Emitting Tricyclic N,O-Heteroaromatics

Disclosed herein is a rhodium-catalyzed oxidative C–H activation/domino annulation of N-Boc-anilines with 1,3-diynes for the construction of tricyclic N,O-heteroaromatics. This reaction features easily available substrates, mild reaction conditions, high regioselectivity, mono/diannulation selectivi...

Full description

Saved in:
Bibliographic Details
Published inOrganic letters Vol. 22; no. 14; pp. 5309 - 5313
Main Authors Qian, Shengyou, Pu, Xingwen, Chang, Guanjun, Huang, Ying, Yang, Yudong
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 17.07.2020
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
DESIGN
RHODIUM-CATALYZED ANNULATION
ARENES
ALKYNES
EMISSION
EMITTERS
AMIDES
Online AccessGet full text

Cover

More Information
Summary:Disclosed herein is a rhodium-catalyzed oxidative C–H activation/domino annulation of N-Boc-anilines with 1,3-diynes for the construction of tricyclic N,O-heteroaromatics. This reaction features easily available substrates, mild reaction conditions, high regioselectivity, mono/diannulation selectivity, and intra/intermolecular annulation selectivity. Moreover, this synthetic protocol enables the rapid assembly of a library of blue-emitting molecules with high quantum yields, among of which two fluorophores with pure blue-emission in toluene are discovered.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.0c01465