Nanorods Formed from a New Class of Peptidomimetics

• Published in: Macromolecules Vol. 45; no. 18; pp. 7350 - 7355
• Main Authors: Niu, Youhong, Wu, Haifan, Huang, Rongfu, Qiao, Qiao, Costanza, Frankie, Wang, Xi-Sen, Hu, Yaogang, Amin, Mohamad Nassir, Nguyen, Anh-My, Zhang, James, Haller, Edward, Ma, Shengqian, Li, Xiao, Cai, Jianfeng
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 25.09.2012
• Subjects: Aminoacids, peptides. Hormones. Neuropeptides; Analytical, structural and metabolic biochemistry; Applied sciences; biocompatibility; Biological and medical sciences; biomimetics; Exact sciences and technology; Fundamental and applied biological sciences. Psychology; nanorods; Natural polymers; Physicochemistry of polymers; Proteins; surfactants; Biomimetics; Peptides; Molecular aggregation; Chiral compound; Peptide synthesis; Aqueous solution; Experimental study; Amphiphilic compound; Nanorod; Mechanism
• ISSN: 0024-9297; 1520-5835; 1520-5835
• DOI: 10.1021/ma3015992

Although peptide amphiphiles have been explored as nanomaterials for different applications, nanostructures formed by hierarchical molecular assembly of sequence-specific peptidomimetics are much less developed. Such protein-like nanomaterials could enhance the current application of peptide-based amphiphiles by enriching the diversity of nanostructures, increasing in vivo stability for biomedical applications, and facilitating the understanding of biomacromolecular self-assembly. Herein we present a biomimetic γ-AApeptide amphiphile which forms nanorods. Our results demonstrate the capability of γ-AApeptide amphiphiles as a potential scaffold for the preparation of biomimetic and bioinspired nanostructures. The programmability and biocompatibility of γ-AApeptides could lead to novel nanomaterials for a wide variety of applications.