Electronic Rearrangement in Steps of Reductive Elimination of Polar Electrophiles Leads to Refinement of Redox Events

• Published in: Organometallics Vol. 42; no. 16; pp. 2171 - 2176
• Main Authors: Basemann, Kevin, Becker, Jennifer J., Windus, Theresa L., Gagné, Michel R.
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 28.08.2023
• Subjects: Alkyls; Anions; Electron density; INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; Ligands; Platinum
• ISSN: 0276-7333; 1520-6041
• DOI: 10.1021/acs.organomet.3c00102

The oxidative addition/reductive elimination of polar molecules such as methyl iodide at late metal centers has a strongly supported SN2 mechanism for many key organometallic complexes, including important industrial catalysts. In the reductive elimination direction, it is proposed that a ligand initially dissociates, typically a halide, followed by subsequent nucleophilic attack at the ligand trans to the now vacant site. The prevailing view is the metal reduction occurs upon transferring the electrophile in the SN2 step. Herein, we report the use of an ensemble of computational techniques to characterize the electronic structure of the reactants and intermediates along this reductive elimination pathway. These calculations demonstrate, unexpectedly, that the initiating loss of an anionic ligand from the octahedral highly oxidized structure leads to an electronic rearrangement that shifts electron density from the apical ligand back toward the metal resulting in an inversion of the electron flow between the metal and apical ligand. The anisotropic shift in electron density to the metal disproportionately affects the apical position, which is best described as a Pt → Me dative bond. With this Pt → Me bonding description, our interpretation of the IUPAC oxidation state formalism would assign the intermediate as PtII. Although counterintuitive, the formal and functional reduction of the metal thus occurs upon halide dissociation.