Construction of an Axially Chiral Fluorene Nitrile-Based Framework via Benzannulation of Indene Diene with Benzoylacetonitrile

The methodology for the synthesis of fluorene-based atropisomers was developed via the strategy of aromatic ring formation. By this strategy, an efficient benzannulation of indene-based diene with benzoylacetonitrile divergently promoted by DABCO and a chiral organocatalyst was established, and vari...

Full description

Saved in:
Bibliographic Details
Published inOrganic letters Vol. 24; no. 45; pp. 8277 - 8282
Main Authors Deng, Yi-Hang, Qin, Lei, Li, Ran, Wang, Yan-Bo, Zhu, Jun-Yan, Fu, Ji-Ya, Zhang, Chuan-Bao, Zhao, Lili
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 18.11.2022
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
ATROPISOMERS
ENANTIOSELECTIVE SYNTHESIS
Online AccessGet full text

Cover

More Information
Summary:The methodology for the synthesis of fluorene-based atropisomers was developed via the strategy of aromatic ring formation. By this strategy, an efficient benzannulation of indene-based diene with benzoylacetonitrile divergently promoted by DABCO and a chiral organocatalyst was established, and various atropisomeric fluorene-based skeletons were generated in good yields, which not only provide a new strategy for the construction of atropisomeric biaryls but also offer a new member to the atropisomeric family.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.2c03179