Rapid Continuous Antisolvent Crystallization of Multicomponent Systems

This paper describes the application of a novel antisolvent crystallization approach to rapid production of tunable solid solutions of hydrophobic amino acids, comprising l-leucine, l-isoleucine, and l-valine. The antisolvent approach provides an alternative to other crystallization routes, e.g., ba...

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Published inCrystal growth & design Vol. 18; no. 1; pp. 210 - 218
Main Authors Raza, Syed A, Schacht, Ulrich, Svoboda, Vaclav, Edwards, Darren P, Florence, Alastair J, Pulham, Colin R, Sefcik, Jan, Oswald, Iain D. H
Format Journal Article
LanguageEnglish
Published American Chemical Society 03.01.2018
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Summary:This paper describes the application of a novel antisolvent crystallization approach to rapid production of tunable solid solutions of hydrophobic amino acids, comprising l-leucine, l-isoleucine, and l-valine. The antisolvent approach provides an alternative to other crystallization routes, e.g., ball-milling, liquid-assisted grinding, and slurry methods, to achieve the required multicomponent solid phases. We report new crystal structures of l-leucine/l-isoleucine and l-leucine/l-valine, and confirm a recent report on a new form of l-isoleucine/l-valine. We used these multicomponent complexes as a test set of materials to demonstrate translation of small scale batch antisolvent crystallization to a continuous production process.
ISSN:1528-7483
1528-7505
DOI:10.1021/acs.cgd.7b01105