In Vitro Effects of Tremorgenic Mycotoxins

• Published in: Journal of natural products (Washington, D.C.) Vol. 54; no. 1; pp. 207 - 212
• Main Authors: Selala, Moss I, Laekeman, Gert M, Loenders, Brigitte, Musuku, Adrien, Herman, Arnold G, Schepens, Paul
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 01.01.1991; Glendale, AZ American Society of Pharmacognosy
• Subjects: Acetylcholine - pharmacology; Animals; Biological and medical sciences; COBAYA; COBAYE; Electric Stimulation; ELECTROPHYSIOLOGY; Female; GUINEA PIGS; ILEUM; Ileum - drug effects; In Vitro Techniques; INTESTIN; INTESTINES; INTESTINOS; Male; Medical sciences; MICOTOXINAS; Molecular Structure; MUSCLE; MUSCLE CONTRACTION; MUSCLES; MUSCULOS; MYCOTOXINE; MYCOTOXINS; Mycotoxins - pharmacology; paxilline; PENICILLIUM; penicillium paxilli; penitrem b; PENITREMS; Plant poisons toxicology; TOXICIDAD; TOXICITE; TOXICITY; Toxicology; TRICHOTHECENE; TRICHOTHECENES; VERRUCULOGEN; Penicillium; Toxicity; Rodentia; Gut; Mycotoxin; Smooth muscle; Muscle contraction; In vitro; Fungi; Toxin; Vertebrata; Mammalia; Guinea pig; Animal; Plant origin; Fungi Imperfecti; Mechanism of action; Thallophyta
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np50073a020

Paxilline was isolated from Penicillium paxilli (NRRL 6110). It was studied together with penitrem B and verruculogen in the electrically stimulated guinea pig ileum. All three mycotoxins enhanced the electrically induced twitch contractions, without influencing the contractions provoked by exogenous acetylcholine. The effect of the mycotoxins could be greatly diminished by hyoscine. The possible mechanism of action of these substances in this in vitro model is discussed. The electrically stimulated guinea pig ileum could be useful in the detection and estimation of the biological activity of tremorgenic mycotoxins.