Terminalia Arjuna ( Roxb. ) Modulates Circulatory Antioxidants on 7,12-dimethylbenz(a)anthracene - induced Hamster Buccal Pouch Carcinogenesis

Oral cancer is the fifth most frequent cancer worldwide and India has recorded the highest incidence (40-50%) of oral malignancy. This study is designed to investigate the effect of aqueous extract of Terminalia arjuna bark (TaBet) on circulatory lipid peroxidation and antioxidant status during 7,12...

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Bibliographic Details
Published inOman medical journal Vol. 25; no. 4; pp. 276 - 281
Main Authors Selvam , Mathi, Dhanarasu , Sasikumar, Salama , Suzan M. Abdel-Tawab
Format Journal Article
LanguageEnglish
Published Muscat - Oman Oman Medical Specialty Board 01.10.2010
OMJ
Subjects
ANTIOXIDANTS
BLOOD CIRCULATION
CANCER
CHEMOPROPHYLAXIS
EPIDERMIS
ERYTHROCYTES
INDIA
LABORATORY ANIMALS
MALIGNANT TUMOURS
MEDICINAL PLANTS
MOUTH DISEASES
Original
TERMINALIA
أمراض الفم
الأورام الخبيثة
الإهليلج
الدورة الدموية
الكريات الحمراء
اللحاء
النباتات الطبية
الهند
الوقاية الكيميائية
حيوانات المختبر
مرض السرطان
مضادات المؤكسد
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Summary:Oral cancer is the fifth most frequent cancer worldwide and India has recorded the highest incidence (40-50%) of oral malignancy. This study is designed to investigate the effect of aqueous extract of Terminalia arjuna bark (TaBet) on circulatory lipid peroxidation and antioxidant status during 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch carcinogenesis. Male Syrian golden hamsters painted with 0.5% 7,12-dimethylbenz[a]anthracene on the buccal pouches and developed oral squamous cell carcinoma were included in this study. The enhanced Thiobarbituric acid reactive substances in circulation of tumor-bearing animals was accompanied by a significant decrease in the levels of vitamin C, vitamin E, reduced glutathione, superoxide dismutase, catalase and glutathione peroxidase. Administration of TaBet (500 mg/kg body weight) significantly suppressed DMBA-induced hamster buccal pouch carcinomas, decreased lipid peroxidation and enhanced the levels of antioxidants. The chemopreventive potential of TaBet is probably due to its antilipidperoxidative effect or the presence of some potent bioactive chemopreventive principles in the bark of Terminalia arjuna. The results of the present study indicate that T. arjuna may emerge as a putative chemopreventive agent against oral carcinogenesis.
ISSN:1999-768X
2070-5204
DOI:10.5001/omj.2010.81