Water-Soluble Colorimetric and Ratiometric Fluorescent Probe for Selective Imaging of Palladium Species in Living Cells

A novel water-soluble colorimetric and ratiometric fluorescent probe was synthesized and applied to imaging palladium species under physiological conditions in phosphate buffered saline (PBS) containing less than 1% organic cosolvent without adding any additional reagents. Based on palladium trigger...

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Published inInorganic chemistry Vol. 53; no. 23; pp. 12590 - 12594
Main Authors Liu, Wei, Jiang, Jie, Chen, Chunyang, Tang, Xiaoliang, Shi, Jinmin, Zhang, Peng, Zhang, Kaiming, Li, Zhiqi, Dou, Wei, Yang, Lizi, Liu, Weisheng
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 01.12.2014
Subjects
Colorimetry - methods
Fluorescent Dyes - chemical synthesis
Fluorescent Dyes - chemistry
Hep G2 Cells
Humans
Molecular Structure
Palladium - chemistry
Water - chemistry
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Summary:A novel water-soluble colorimetric and ratiometric fluorescent probe was synthesized and applied to imaging palladium species under physiological conditions in phosphate buffered saline (PBS) containing less than 1% organic cosolvent without adding any additional reagents. Based on palladium triggered terminal propargyl ethers cleavage reaction, the probe exhibited a high selectivity and sensitivity for palladium species of all the typical oxidation states (0, +2, +4), with a low detection limit (25 nM, 2.7 μg/L) and an obvious color change. Furthermore, the probe was successfully used for ratiometric fluorescence imaging of palladium in living cells.
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content type line 23
ISSN:0020-1669
1520-510X
DOI:10.1021/ic502223n