Chemoselective Palladium-Catalyzed Cyanation of Alkenyl Halides

A palladium-catalyzed cyanation of alkenyl halides using acetone cyanohydrin is described. A number of structurally diverse alkenylic nitrile containing compounds was prepared in one step under optimized conditions. The reaction proved to be efficient, chemoselective, easy to perform, and tolerant o...

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Bibliographic Details
Published inOrganic letters Vol. 16; no. 8; pp. 2158 - 2161
Main Authors Powell, Kimberley J, Han, Li-Chen, Sharma, Pallavi, Moses, John E
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 18.04.2014
Amer Chemical Soc
Subjects
Alkenes - chemical synthesis
Alkenes - chemistry
Catalysis
Chemistry
Chemistry, Organic
Combinatorial Chemistry Techniques
Hydrocarbons, Brominated - chemical synthesis
Hydrocarbons, Brominated - chemistry
Molecular Structure
Nitriles - chemical synthesis
Nitriles - chemistry
Palladium - chemistry
Physical Sciences
Science & Technology
WITTIG-HORNER
NITRILES
DEHYDRATION
MICROWAVE
PRIMARY AMIDES
ARYL HALIDES
COMPLEXES
ALPHA,BETA-UNSATURATED CYANIDES
STEREOSELECTIVE CARBONYL OLEFINATION
VINYL HALIDES
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Summary:A palladium-catalyzed cyanation of alkenyl halides using acetone cyanohydrin is described. A number of structurally diverse alkenylic nitrile containing compounds was prepared in one step under optimized conditions. The reaction proved to be efficient, chemoselective, easy to perform, and tolerant of a number of functional groups.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1523-7060
1523-7052
DOI:10.1021/ol500618w