Copper-Catalyzed Trifluoromethylthiolation of Aryl Halides with Diverse Directing Groups

The expansion of cross-coupling components in Cu-catalyzed C–X bond forming reactions have received much attention recently. A novel Cu-catalyzed trifluoromethylthiolation of aryl bromides and iodides with the assistance of versatile directing groups such as pyridyl, methyl ester, amide, imine and o...

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Published inOrganic letters Vol. 16; no. 15; pp. 3942 - 3945
Main Authors Xu, Jiabin, Mu, Xin, Chen, Pinhong, Ye, Jinxing, Liu, Guosheng
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 01.08.2014
Amer Chemical Soc
Subjects
Catalysis
Chemistry
Chemistry, Organic
Copper - chemistry
Hydrocarbons, Brominated - chemistry
Hydrocarbons, Fluorinated - chemical synthesis
Hydrocarbons, Fluorinated - chemistry
Hydrocarbons, Iodinated - chemistry
Molecular Structure
Physical Sciences
Science & Technology
Sulfhydryl Compounds - chemistry
Temperature
BORONIC ACIDS
FLUORINE
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Summary:The expansion of cross-coupling components in Cu-catalyzed C–X bond forming reactions have received much attention recently. A novel Cu-catalyzed trifluoromethylthiolation of aryl bromides and iodides with the assistance of versatile directing groups such as pyridyl, methyl ester, amide, imine and oxime was reported. CuBr was used as the catalyst, and 1,10-phenanthroline as the ligand. By changing the solvent from acetonitrile to DMF, the coupling process could even take place at room temperature.
Bibliography:ObjectType-Article-1
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content type line 23
ISSN:1523-7060
1523-7052
DOI:10.1021/ol501742a