Stimuli-Responsive and Hemocompatible Pseudozwitterionic Interfaces

We report a novel biomacromolecular formula for the design of hemocompatible gel interfaces of N-isopropylacrylamide (NIPAAm) and mixed-charge pairs of [2-(methacryloyloxy)­ethyl]­trimethyl­ammonium (TMA) and 3-sulfopropyl methacrylate (SA) with overall electrical neutrality. The study stresses on h...

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Bibliographic Details
Published inLangmuir Vol. 31; no. 9; pp. 2861 - 2869
Main Authors Venault, Antoine, Zheng, Yong-Sheng, Chinnathambi, Arunachalam, Alharbi, Sulaiman Ali, Ho, Hsin-Tsung, Chang, Yu, Chang, Yung
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 10.03.2015
Subjects
Acrylamides - chemistry
Bacterial Adhesion - drug effects
Biocompatible Materials - chemistry
Biocompatible Materials - pharmacology
Biofouling - prevention & control
Blood Coagulation - drug effects
Cell Adhesion - drug effects
Hemolysis - drug effects
Humans
Hydrogels - chemistry
Hydrogen-Ion Concentration
Leukocytes - cytology
Leukocytes - drug effects
Methacrylates - chemistry
Models, Molecular
Molecular Conformation
Osmolar Concentration
Polymers - chemistry
Polymers - pharmacology
Temperature
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Summary:We report a novel biomacromolecular formula for the design of hemocompatible gel interfaces of N-isopropylacrylamide (NIPAAm) and mixed-charge pairs of [2-(methacryloyloxy)­ethyl]­trimethyl­ammonium (TMA) and 3-sulfopropyl methacrylate (SA) with overall electrical neutrality. The study stresses on how well-defined compositions of nonionic NIPAAm and pseudozwitterionic TMA/SA in the poly­(NIPAAm-co-TMA/SA) hydrogels along with environmental conditions (temperature, ionic strength, and solution pH) affect swelling and adhesion of biofoulants on their surfaces. When challenged with plasma proteins, bacteria, recalcified platelets, or whole blood, stimuli-responsive hydrogels better resisted their adhesion as the content of mixed charges in the copolymer increased, to reach nonbiofouling for the gels made of 100% TMA/SA. The low hemolytic activity (0.5%) associated with a long plasma clotting time (10 min) suggests excellent hemocompatibility excellent hemocompatibility. Finally, hydrogels containing both NIPAAm and TMA/SA tend to exhibit preferential adhesion of leukocytes.
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ISSN:0743-7463
1520-5827
DOI:10.1021/la505000m