Generation of Nitrile Oxides from Oximes Using t-BuOI and Their Cycloaddition

tert-Butyl hypoiodite (t-BuOI) was found to be a powerful reagent for the cycloaddition of oximes and alkenes/alkynes, leading to the formation of a variety of isoxazolines or isoxazoles under mild conditions.

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Bibliographic Details
Published inOrganic letters Vol. 13; no. 11; pp. 2966 - 2969
Main Authors Minakata, Satoshi, Okumura, Sota, Nagamachi, Toshiki, Takeda, Youhei
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 03.06.2011
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
HETEROCYCLES
PRIMARY NITROCOMPOUNDS
HYDROXIMOYL CHLORIDES
ISOXAZOLINE
DEHYDRATION
OLEFINS
BENZISOXAZOLES
DERIVATIVES
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Summary:tert-Butyl hypoiodite (t-BuOI) was found to be a powerful reagent for the cycloaddition of oximes and alkenes/alkynes, leading to the formation of a variety of isoxazolines or isoxazoles under mild conditions.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1523-7060
1523-7052
DOI:10.1021/ol2010616