Palladium-Catalyzed Cross-Coupling of H-Phosphinate Esters with Chloroarenes

• Published in: Organic letters Vol. 13; no. 12; pp. 3270 - 3273
• Main Authors: Deal, Eric L, Petit, Christelle, Montchamp, Jean-Luc
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 17.06.2011; Amer Chemical Soc
• Subjects: Catalysis; Chemistry; Chemistry, Organic; Esters; Hydrocarbons, Chlorinated - chemistry; Molecular Structure; Organophosphorus Compounds - chemical synthesis; Organophosphorus Compounds - chemistry; Palladium - chemistry; Physical Sciences; Science & Technology; HYDROPHOSPHINYLATION; P-ARYLATION; RECEPTOR ANTAGONISTS; ELEMENTAL PHOSPHORUS; ACIDS; P-4 ACTIVATION; ARYL; WHITE PHOSPHORUS; DERIVATIVES; PHOSPHORUS-CARBON BOND

The palladium-catalyzed cross-coupling reaction between H-phosphinate esters and chloroarenes or chloroheteroarenes is described. This reaction is the first general metal-catalyzed phosphorus–carbon bond-forming reaction between a phosphorus nucleophile and chloroarenes.