Palladium-Catalyzed Cross-Coupling of H-Phosphinate Esters with Chloroarenes

The palladium-catalyzed cross-coupling reaction between H-phosphinate esters and chloroarenes or chloroheteroarenes is described. This reaction is the first general metal-catalyzed phosphorus–carbon bond-forming reaction between a phosphorus nucleophile and chloroarenes.

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Bibliographic Details
Published inOrganic letters Vol. 13; no. 12; pp. 3270 - 3273
Main Authors Deal, Eric L, Petit, Christelle, Montchamp, Jean-Luc
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 17.06.2011
Amer Chemical Soc
Subjects
Catalysis
Chemistry
Chemistry, Organic
Esters
Hydrocarbons, Chlorinated - chemistry
Molecular Structure
Organophosphorus Compounds - chemical synthesis
Organophosphorus Compounds - chemistry
Palladium - chemistry
Physical Sciences
Science & Technology
HYDROPHOSPHINYLATION
P-ARYLATION
RECEPTOR ANTAGONISTS
ELEMENTAL PHOSPHORUS
ACIDS
P-4 ACTIVATION
ARYL
WHITE PHOSPHORUS
DERIVATIVES
PHOSPHORUS-CARBON BOND
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Summary:The palladium-catalyzed cross-coupling reaction between H-phosphinate esters and chloroarenes or chloroheteroarenes is described. This reaction is the first general metal-catalyzed phosphorus–carbon bond-forming reaction between a phosphorus nucleophile and chloroarenes.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1523-7060
1523-7052
DOI:10.1021/ol201222n