[C+NC+CC] Coupling-Enabled Synthesis of Influenza Neuramidase Inhibitor A-315675

An efficient synthesis of the neuramidase inhibitor A-315675 is reported. The fully functionalized pyrrolidine core of the target is assembled in one pot via an exo-selective asymmetric [C+NC+CC] coupling reaction.

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Bibliographic Details
Published inOrganic letters Vol. 14; no. 5; pp. 1326 - 1329
Main Authors Garner, Philip, Weerasinghe, Laksiri, Youngs, Wiley J, Wright, Brian, Wilson, Dean, Jacobs, Dylan
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 02.03.2012
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Organic
Enzyme Inhibitors - chemical synthesis
Models, Molecular
Molecular Structure
Neuraminidase - antagonists & inhibitors
Orthomyxoviridae - enzymology
Physical Sciences
Pyrrolidines - chemical synthesis
Science & Technology
Stereoisomerism
RESISTANT
NEURAMINIDASE INHIBITOR
CYANOCYCLINE
VIRUSES
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Summary:An efficient synthesis of the neuramidase inhibitor A-315675 is reported. The fully functionalized pyrrolidine core of the target is assembled in one pot via an exo-selective asymmetric [C+NC+CC] coupling reaction.
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ISSN:1523-7060
1523-7052
DOI:10.1021/ol3002128