Surface-Mediated DNA Self-Assembly

This communication reports a strategy for solid surface-mediated DNA self-assembly. DNA molecules weakly interact with solid surfaces; thus are confined to solid surfaces. The confinement reduces the flexibility of DNA nanomotifs and promotes the DNA 2D crystals to grow on solid surfaces. As a demon...

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Bibliographic Details
Published inJournal of the American Chemical Society Vol. 131; no. 37; pp. 13248 - 13249
Main Authors Sun, Xuping, Hyeon Ko, Seung, Zhang, Chuan, Ribbe, Alexander E, Mao, Chengde
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 23.09.2009
Subjects
Aluminum Silicates - chemistry
DNA - chemistry
Microscopy, Atomic Force
Oligonucleotide Array Sequence Analysis
Solutions
Surface Properties
Temperature
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Summary:This communication reports a strategy for solid surface-mediated DNA self-assembly. DNA molecules weakly interact with solid surfaces; thus are confined to solid surfaces. The confinement reduces the flexibility of DNA nanomotifs and promotes the DNA 2D crystals to grow on solid surfaces. As a demonstration, periodic DNA nanoarrays have been directly assembled onto mica surfaces. Such in situ assembly eliminates the sample transfer process between assembly and characterization and possible applications.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0002-7863
1520-5126
DOI:10.1021/ja906475w